Publications
2024
Hector M, Langmann T, Wolf A. Translocator protein (18 kDa) (TSPO) in the retina and implications for ocular diseases. Prog Retin Eye Res. 2024 Mar 1;100:101249.
Laudenberg N, Kinuthia UM, Langmann T. Microglia depletion/repopulation does not affect light-induced retinal degeneration in mice. Front Immunol. 2024 Jan 15; 14:1345382
2023
Nuzhat N, Van Schil K, Liakopoulos S, Bauwens M, Dueñas Rey A, Käseberg S, Jäger M, Willer JR, Winter J, Truong HM, Gruartmoner N, Van Heetvelde M, Wolf JC, Merget R, Grasshoff-Derr S, Van Dorpe J, Hoorens A, Stöhr H, Mansard L, Roux AF, Langmann T, Dannhausen K, Rosenkranz D, Wissing KM, Van Lint M, Rossmann H, Häuser F, Nürnberg P, Thiele H, Zechner U, Pearring JN, De Baere E, Bolz HJ. CEP162 deficiency causes human retinal degeneration and reveals a dual role in ciliogenesis and neurogenesis. J Clin Invest. 2023 Mar 2:e161156.
Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P. Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation. Science. 2023 Jan 6;379(6627):45-62.
2022
Tabel M, Wolf A, Szczepan M, Xu H, Jägle H, Moehle C, Chen M, Langmann T. Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration. J Neuroinflammation. 2022 Sep 17;19(1):229.
Hansen JN, Brückner M, Pietrowski MJ, Jikeli JF, Plescher M, Beckert H, Schnaars M, Fülle L, Reitmeier K, Langmann T, Förster I, Boche D, Petzold GC, Halle A. MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia. Mol Biol Cell. 2022 Sep 15;33(11):ar99.
2021
Khan AS, Wolf A, Langmann T. The AhR ligand 2, 2'aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro inflammatory signaling. Biochem Biophys Res Commun. 2021 nov 19;579:15-21
Langmann T. Cytokine signaling as key rehulator of pathological angiogenesis in the eye. EBioMedicine. 2021 nov;73:103662
Uemura A, Fruttiger M, D'Amore PA, De Falco S, Joussen AM, Sennlaub F, Brunck LR, Johnson KT, Lambrou GN, Rittenhouse KD, Langmann T. VEGFR1 signaling in retinal angiogenesis and microinflammation. Prog Retin Eye Res. 2021 Sep;84:100954
ChanYK, Dick AD, all SM, Langmann T, Scribner CL, Mansfield BC; Ocular Gene Therapy Inflammation Working Group. Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020. Transl Vis sci Technol. 2021 Apr 1;10(4):3
Díaz-Lezama N, Wolf A, Koch S, Pfaller AM, Biber J, Guillonneau X, Langmann T, Grosche A. PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis Functions. Int J Mol Sci. 2021 Jan 25;22(3):1174.
2020
Behnke V, Langmann T. IFN-β signaling dampens microglia reactivity but does not prevent from light-induced retinal degeneration. Biochem Biophys Rep. 2020 Nov 26;24:100866.
Kinuthia UM, Wolf A, Langmann T. Microglia and Inflammatory Responses in Diabetic Retinopathy. Front Immunol. 2020 Nov 6;11:564077.
Khan AS, Langmann T. Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration. J Neuroinflammation. 2020 Nov 3;17(1):327.
Strunz T, Kiel C, Grassmann F, Ratnapriya R, Kwicklis M, Karlstetter M, Fauser S, Arend N, Swaroop A, Langmann T, Wolf A, Weber BHF. A mega-analysis of expression quantitative trait loci in retinal tissue. PLoS Genet. 2020 Sep 1;16(9):e1008934.
Rashid K, Verhoyen M, Taiwo M, Langmann T. Translocator protein (18kDa) (TSPO) ligands activate Nrf2 signaling and attenuate inflammatory responses and oxidative stress in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2020 Jul 23; 528(2):261-268.
Wolf A, Herb M, Schramm M, Langmann T. The TSPO-NOX1 axis controls phagocyte-triggered pathological angiogenesis in the eye. Nat Commun. 2020 Jun 1; 11(1):2709.
Kiel C, Berber P, Karlstetter M, Aslanidis A, Strunz T, Langmann T, Grassmann F, Weber BHF. A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization. Int J Mol Sci. 2020 Apr 13;21(8).
Wasmuth S, Jalilvand TV, Laffer B, Busch M, Bauer D, Langmann T, Thanos S, Kasper M, Heiligenhaus A. Phenotypic Differences in Primary Murine Microglia Treated with NOD1, NOD2, and NOD1/2 Agonists. J Mol Neurosci. 2020 Apr;70(4):600-609.
Sitnilska V, Kersten E, Altay L, Schick T, Enders P, de Jong EK, Langmann T, Hoyng CB, den Hollander AI, Fauser S. Major predictive factors for progression of early to late age-related macular degeneration. Ophthalmologica. 2020 Mar 13.
Kasper M, Walscheid K, Laffer B, Bauer D, Busch M, Loser K, Vogl T, Langmann T, Ganser G, Rath T, Heiligenhaus A. Phenotype of Innate Immune Cells in Uveitis Associated with Axial Spondyloarthritis- and Juvenile Idiopathic Arthritis-associated Uveitis. Ocul Immunol Inflamm. 2020 Mar 11:1-10.
Behnke V, Wolf A, Langmann T. The role of lymphocytes and phagocytes in age-related macular degeneration (AMD). Cell Mol Life Sci. 2020 Mar;77(5):781-788.
Strunz T, Lauwen S, Kiel C; International AMD Genomics Consortium (IAMDGC), Hollander AD, Weber BHF. A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration. Sci Rep. 2020 Jan 31;10(1):1584.
2019
Klee K, Storti F, Barben M, Samardzija M, Langmann T, Dunaief J, Grimm C. Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration. Exp Eye Res. 2019 Nov;188:107816.
Laffer B, Bauer D, Wasmuth S, Busch M, Jalilvand TV, Thanos S, Meyer Zu Hörste G, Loser K, Langmann T, Heiligenhaus A, Kasper M. Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype. Front Cell Neurosci. 2019 Oct 9;13:430.
Rashid K, Akhtar-Schaefer I, Langmann T. Microglia in Retinal Degeneration. Front Immunol. 2019 Aug 20;10:1975.
Van Schil K, Naessens S, Van de Sompele S, Carron M, Aslanidis A, Van Cauwenbergh C, Mayer AK, Van Heetvelde M, Bauwens M, Verdin H, Coppieters F, Greenberg ME, Yang MG, Karlstetter M, Langmann T, De Preter K, Kohl S, Cherry TJ, Leroy BP; CNV Study Group, De Baere E. Correction: Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations. Genet Med. 2019 Aug;21(8):1998.
Wolf A, Langmann T. Anti-VEGF-A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study. EMBO Mol Med. 2019 May;11(5).
Balser C, Wolf A, Herb M, Langmann T. Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina. J Neuroinflammation. 2019 Feb 7;16(1):26.
Volz C, Mirza M, Langmann T, Jägle H. ERG Alteration Due to the rd8 Mutation of the Crb1 Gene in Cln3 (+/+ rd8-/rd8-) Mice. Adv Exp Med Biol. 2019;1185:395-400.
Akhtar-Schaefer I, Reuten R, Koch M, Pietsch M, Langmann T. AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia. Adv Exp Med Biol. 2019;1185:3-7.
Rashid K, Dannhausen K, Langmann T. Testing for Known Retinal Degeneration Mutants in Mouse Strains. Methods Mol Biol. 2019;1834:45-58.
2018
Rashid K, Geissl L, Wolf A, Karlstetter M, Langmann T. Transcriptional regulation of Translocator protein (18 kDa) (TSPO) in microglia requires Pu.1, Ap1 and Sp factors. Biochim Biophys Acta Gene Regul Mech. 2018 Dec;1861(12):1119-1133.
Akhtar-Schäfer I, Wang L, Krohne TU, Xu H, Langmann T. Modulation of three key innate immune pathways for the most common retinal degenerative diseases. EMBO Mol Med. 2018 Oct;10(10).
Dannhausen K, Möhle C, Langmann T. Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis mice highly susceptible to light damage. Dis Model Mech. 2018 Sep 5;11(9).
Di Pierdomenico J, Scholz R, Valiente-Soriano FJ, Sánchez-Migallón MC, Vidal-Sanz M, Langmann T, Agudo-Barriuso M, García-Ayuso D, Villegas-Pérez MP. Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4392-4403.
Kasper M, Walscheid K, Laffer B, Bauer D, Busch M, Wildschütz L, Wang B, Loser K, Vogl T, Grajewski RS, Langmann T, Heiligenhaus A. The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status. Front Immunol. 2018 Jul 30;9:1773.
Rashid K, Wolf A, Langmann T. Microglia Activation and Immunomodulatory Therapies for Retinal Degenerations. Front Cell Neurosci. 2018 Jun 21;12:176.
Wiedemann J, Rashid K, Langmann T. Resveratrol induces dynamic changes to the microglia transcriptome, inhibiting inflammatory pathways and protecting against microglia-mediated photoreceptor apoptosis. Biochem Biophys Res Commun. 2018 Jun 18;501(1):239-245.
Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T. Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina. Sci Rep. 2018 Apr 13;8(1):5970.
Madeira MH, Rashid K, Ambrósio AF, Santiago AR, Langmann T. Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro. Sci Rep. 2018 Feb 2;8(1):2272.
Van Schil K, Naessens S, Van de Sompele S, Carron M, Aslanidis A, Van Cauwenbergh C, Kathrin Mayer A, Van Heetvelde M, Bauwens M, Verdin H, Coppieters F, Greenberg ME, Yang MG, Karlstetter M, Langmann T, De Preter K, Kohl S, Cherry TJ, Leroy BP; CNV Study Group, De Baere E. Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations. Genet Med. 2018 Feb;20(2):202-213.
Volz C, Mirza M, Langmann T, Jägle H. Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 (Δex7/8) Knock-In Mice. Adv Exp Med Biol. 2018;1074:403-411
Dannhausen K, Rashid K, Langmann T. Microglia Analysis in Retinal Degeneration Mouse Models. Methods Mol Biol. 2018;1753:159-166.
2017
Lückoff A, Scholz R, Sennlaub F, Xu H, Langmann T. Comprehensive analysis of mouse retinal mononuclear phagocytes. Nat Protoc. 2017 Jun; 12(6):1136-1150.
Langmann T, Fauser S. [Polysialic Acid for Immunomodulation in an Animal Model for Wet Age-Related Macular Degeneration (AMD)]. Klin Monbl Augenheilkunde. 2017 Apr 5.
Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark; International AMD Genomics Consortium (IAMDGC)., Heid IM, Weber BH, ...Langmann T. Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Med. 2017 Mar 27;9(1):29.
Nebel C, Aslanidis A, Rashid K, Langmann T. Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells. Biochem Biophys Res Commun. 2017 Mar 11;484(3):681-686.
Martens TF, Peynshaert K, Nascimento TL, Fattal E, Karlstetter M, Langmann T, Picaud S, Demeester J, De Smedt SC, Remaut K, Braeckmans K. Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy. Eur J Pharm Sci. 2017 Feb 20.
Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H. Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina. EMBO Mol Med. 2017 Feb;9(2):154-166.
Wolf A, Aslanidis A, Langmann T. Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression. Biochem Biophys Res Commun. 2017 Jan 29;483(1):346-351.
Schick T, Steinhauer M, Aslanidis A, Altay L, Karlstetter M, Langmann T, Kirschfink M, Fauser S. Local complement activation in aqueous humor in patients with age-related macular degeneration. Eye (Lond). 2017 Jan 27.
Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C. Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation. 2017 Jan 5;14(1):4.
2016
Scholz R, Langmann T. Gut flora connects obesity with pathological angiogenesis in the eye. EMBO Mol Med. 2016 Dec 1;8(12):1361-1363.
Altay L, Scholz P, Schick T, Felsch M, Hoyng CB, den Hollander AI, Langmann T, Fauser S.Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4315-20.
Coppieters F, Ascari G, Dannhausen K, Nikopoulos K, Peelman F, Karlstetter M, Xu M, Brachet C, Meunier I, Tsilimbaris MK, Tsika C, Blazaki SV, Vergult S, Farinelli P, Van Laethem T, Bauwens M, De Bruyne M, Chen R, Langmann T, Sui R, Meire F, Rivolta C, Hamel CP, Leroy BP, De Baere E. Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination. Am J Hum Genet. 2016 Aug 4;99(2):470-480.
Lückoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T. Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization. EMBO Mol Med. 2016 May 3.
Zeilbeck LF, Müller BB, Leopold SA, Senturk B, Langmann T, Tamm ER, Ohlmann A. Norrin mediates angiogenic properties via the induction of insulin-like growth factor-1. Exp Eye Res. 2016 Apr;145:317-26.
Van Schil K, Karlstetter M, Aslanidis A, Dannhausen K, Azam M, Qamar R, Leroy BP, Depasse F, Langmann T, De Baere E. Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7. Sci Rep. 2016 Feb 18;6:21307.
Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M, Kim IK, Cho D, Zack D, Souied E, Scholl HP, Bala E, Lee KE, Hunter DJ, Sardell RJ, Mitchell P, Merriam JE, Cipriani V, Hoffman JD, Schick T, Lechanteur YT, Guymer RH, Johnson MP, Jiang Y, Stanton CM, Buitendijk GH, Zhan X, Kwong AM, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham KE, Foerster JR, Heckenlively JR, Othman MI, Vote BJ, Liang HH, Souzeau E, McAllister IL, Isaacs T, Hall J, Lake S, Mackey DA, Constable IJ, Craig JE, Kitchner TE, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz CN, Wolf A, Brandl C, Rudolph G, Olden M, Morrison MA, Morgan DJ, Schu M, Ahn J, Silvestri G, Tsironi EE, Park KH, Farrer LA, Orlin A, Brucker A, Li M, Curcio CA, Mohand-Saïd S, Sahel JA, Audo I, Benchaboune M, Cree AJ, Rennie CA, Goverdhan SV, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz FG, Blond F, Blanché H, Deleuze JF, Igo RP Jr, Truitt B, Peachey NS, Meuer SM, Myers CE, Moore EL, Klein R, Hauser MA, Postel EA, Courtenay MD, Schwartz SG, Kovach JL, Scott WK, Liew G, Tan AG, Gopinath B, Merriam JC, Smith RT, Khan JC, Shahid H, Moore AT, McGrath JA, Laux R, Brantley MA Jr, Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens NT, de Jong EK, Hoyng CB, Cain MS, Richardson AJ, Martin TM, Blangero J, Weeks DE, Dhillon B, van Duijn CM, Doheny KF, Romm J, Klaver CC, Hayward C, Gorin MB, Klein ML, Baird PN, den Hollander AI, Fauser S, Yates JR, Allikmets R, Wang JJ, Schaumberg DA, Klein BE, Hagstrom SA, Chowers I, Lotery AJ, Léveillard T, Zhang K, Brilliant MH, Hewitt AW, Swaroop A, Chew EY, Pericak-Vance MA, DeAngelis M, Stambolian D, Haines JL, Iyengar SK, Weber BH, Abecasis GR, Heid IM. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016 Feb;48(2):134-43.
2015
Scholz R, Sobotka M, Caramoy A, Stempfl T, Moehle C, Langmann T. Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation. 2015 Nov 17;12:209.
Scholz R, Caramoy A, Bhuckory MB, Rashid K, Chen M, Xu H, Grimm C, Langmann T. Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration. J Neuroinflammation. 2015 Nov 2;12(1):201.
Langmann T. Intracellular Toll-Like Receptors Help Retinal Microglia Sense Corneal Infections. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7387.
Dannhausen K, Karlstetter M, Caramoy A, Volz C, Jägle H, Liebisch G, Utermöhlen O, Langmann T. Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function. Biochem Biophys Res Commun. 2015 Aug 21;464(2):434-40.
Aslanidis A, Karlstetter M, Scholz R, Fauser S, Neumann H, Fried C, Pietsch M, Langmann T. Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia. J Neuroinflammation. 2015 Apr 19;12:77.
Van Schil K, Meire F, Karlstetter M, Bauwens M, Verdin H, Coppieters F, Scheiffert E, Van Nechel C, Langmann T, Deconinck N, De Baere E. Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion. Genet Med. 2015 Apr;17(4):291-9.
Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, Langmann T. Retinal microglia: just bystander or target for therapy? Prog Retin Eye Res. 2015 Mar;45:30-57.
Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, Holtman IR, Wang X, Eggen BJ, Boddeke HW, Hambardzumyan D, Wolf SA, Kettenmann H. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS One. 2015 Feb 6;10(2):e0116644.
2014
Karlstetter M, Sorusch N, Caramoy A, Dannhausen K, Aslanidis A, Fauser S, Boesl MR, Nagel-Wolfrum K, Tamm ER, Jägle H, Stoehr H, Wolfrum U, Langmann T. Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration. Hum Mol Genet. 2014 Oct 1;23(19):5197-210.
Ersoy L, Ristau T, Hahn M, Karlstetter M, Langmann T, Dröge K, Caramoy A, den Hollander AI, Fauser S. Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older. Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1842-7.
Langmann T, Ueffing M, Kirchhof B, Holz FG, Pauleikhoff D. [Meeting report -- retinal research 2013 in Germany]. Klin Monbl Augenheilkd. 2014 Mar;231(3):266-8.
Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014 Jan 8;11:3.
Volz C, Mirza M, Langmann T, Jägle H. Retinal function in aging homozygous Cln3 (Δex7/8) knock-in mice. Adv Exp Med Biol. 2014;801:495-501.
Karlstetter M, Langmann T. Microglia in the aging retina. Adv Exp Med Biol. 2014;801:207-12.
Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T. RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). Adv Exp Med Biol. 2014;801:31-41.
2013
Langmann T. Class A scavenger receptors shed light on immune cell recruitment and CNV. Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):5971.
Zollbrecht C, Grassl M, Fenk S, Höcherl R, Hubauer U, Reinhard W, Esslinger UB, Ebert S, Langmann T, Stark K, Hengstenberg C. Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus. Atherosclerosis. 2013 Apr;227(2):244-9.
Groh J, Kühl TG, Ip CW, Nelvagal HR, Sri S, Duckett S, Mirza M, Langmann T, Cooper JD, Martini R. Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis. Brain. 2013 Apr;136(Pt 4):1083-101.
Mirza M, Volz C, Karlstetter M, Langiu M, Somogyi A, Ruonala MO, Tamm ER, Jägle H, Langmann T. Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. PLoS One. 2013 Oct 4;8(10):e75963.
Hlawatsch J, Karlstetter M, Aslanidis A, Lückoff A, Walczak Y, Plank M, Böck J, Langmann T. Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina. PLoS One. 2013;8(4):e60633.
2012
Zach F, Grassmann F, Langmann T, Sorusch N, Wolfrum U, Stöhr H. The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association. Hum Mol Genet. 2012 Nov 1;21(21):4573-86.
Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, Langmann T, Singer S, Klingseisen L, Schneider-Brachert W, Toll A, Real FX, Landthaler M, Hafner C. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat Genet. 2012 Jun 10;44(7):783-7.
Karlstetter M, Langmann T. [Immune mechanisms in retinal degeneration]. Klin Monbl Augenheilkd. 2012 Mar;229(3):221-6.
Ebert S, Walczak Y, Remé C, Langmann T. Microglial activation and transcriptomic changes in the blue light-exposed mouse retina. Adv Exp Med Biol. 2012;723:619-32.
2011
Karlstetter M, Lippe E, Walczak Y, Moehle C, Aslanidis A, Mirza M, Langmann T. Curcumin is a potent modulator of microglial gene expression and migration. J Neuroinflammation. 2011 Sep 29;8:125.
Kraus D, Karlstetter M, Walczak Y, Hilfinger D, Langmann T, Weber BH. Retinal expression of the X-linked juvenile retinoschisis (RS1) gene is controlled by an upstream CpG island and two opposing CRX-bound regions. Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):245-54.
Friedrich U, Stöhr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, Weber BH. The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis. Hum Mol Genet. 2011 Mar 15;20(6):1132-42.
Lachos J, Zattoni M, Wieser HG, Fritschy JM, Langmann T, Schmitz G, Errede M, Virgintino D, Yonekawa Y, Frei K. Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsy Res Treat. 2011;2011:758407.
2010
Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T. CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors. Genome Res. 2010 Nov;20(11):1512-25.
Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T. The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response. J Immunol. 2010 Sep 15;185(6):3379-90.
Langmann T, Di Gioia SA, Rau I, Stöhr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M, Arsenijevic Y, Weber BH, Gal A, Rivolta C. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet. 2010 Sep 10;87(3):376-81.
Langmann T, Rehli M. Immunobiology. Editorial. Immunobiology. 2010 Sep-Oct;215(9-10):673.
Karlstetter M, Ebert S, Langmann T. Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology. 2010 Sep-Oct;215(9-10):685-91.
Ugocsai P, Hohenstatt A, Paragh G, Liebisch G, Langmann T, Wolf Z, Weiss T, Groitl P, Dobner T, Kasprzak P, Göbölös L, Falkert A, Seelbach-Goebel B, Gellhaus A, Winterhager E, Schmidt M, Semenza GL, Schmitz G. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. Int J Biochem Cell Biol. 2010 Feb;42(2):241-52.
Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation. 2010 Jan 14;7:3. Erratum in: J Neuroinflammation. 2012;9:118.
2009
Ebert S, Weigelt K, Walczak Y, Drobnik W, Mauerer R, Hume DA, Weber BH, Langmann T. Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. J Neurochem. 2009 Sep;110(6):1863-75.
Lutter D, Langmann T, Ugocsai P, Moehle C, Seibold E, Splettstoesser WD, Gruber P, Lang EW, Schmitz G. Analyzing time-dependent microarray data using independent component analysis derived expression modes from human macrophages infected with F. tularensis holartica. J Biomed Inform. 2009 Aug;42(4):605-11.
Hendig D, Langmann T, Zarbock R, Schmitz G, Kleesiek K, Götting C. Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line. Mol Cell Biochem. 2009 Aug;328(1-2):85-92.
Gnewuch C, Liebisch G, Langmann T, Dieplinger B, Mueller T, Haltmayer M, Dieplinger H, Zahn A, Stremmel W, Rogler G, Schmitz G. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol. 2009 Jul 7;15(25):3134-41.
Weigelt K, Lichtinger M, Rehli M, Langmann T. Transcriptomic profiling identifies a PU.1 regulatory network in macrophages. Biochem Biophys Res Commun. 2009 Mar 6;380(2):308-12.
Mauerer R, Ebert S, Langmann T. High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages. Exp Mol Med. 2009 Feb 28;41(2):126-32.
Stoecker K, Weigelt K, Ebert S, Karlstetter M, Walczak Y, Langmann T. Induction of STAP-1 promotes neurotoxic activation of microglia. Biochem Biophys Res Commun. 2009 Jan 30;379(1):121-6.
Mauerer R, Walczak Y, Langmann T. Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays. Methods Mol Biol. 2009;580:187-201.
Langmann T, Ebert S, Walczak Y, Weigelt K, Ehrengruber MU, Stiewe T, Weber BH. Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo. Neuromolecular Med. 2009;11(2):87-96.
2008
Paragh G, Schling P, Ugocsai P, Kel AE, Liebisch G, Heimerl S, Moehle C, Schiemann Y, Wegmann M, Farwick M, Wikonkál NM, Mandl J, Langmann T, Schmitz G. Novel sphingolipid derivatives promote keratinocyte differentiation. Exp Dermatol. 2008 Dec;17(12):1004-16.
Hendig D, Langmann T, Kocken S, Zarbock R, Szliska C, Schmitz G, Kleesiek K, Götting C. Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis. Lab Invest. 2008 Dec;88(12):1303-15.
Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH. CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene. Nucleic Acids Res. 2008 Nov;36(20):6523-34.
Florian C, Langmann T, Weber BH, Morsczeck C. Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells. Biochem Biophys Res Commun. 2008 Sep 19;374(2):187-91.
Van den Brulle J, Fischer M, Langmann T, Horn G, Waldmann T, Arnold S, Fuhrmann M, Schatz O, O'Connell T, O'Connell D, Auckenthaler A, Schwer H. A novel solid phase technology for high-throughput gene synthesis. Biotechniques. 2008 Sep;45(3):340-3.
Ebert S, Schoeberl T, Walczak Y, Stoecker K, Stempfl T, Moehle C, Weber BH, Langmann T. Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype. J Leukoc Biol. 2008 Sep;84(3):736-40.
Weigelt K, Moehle C, Stempfl T, Weber B, Langmann T. An integrated workflow for analysis of ChIP-chip data. Biotechniques. 2008 Aug;45(2):131-2, 134, 136
Milenkovic VM, Langmann T, Schreiber R, Kunzelmann K, Weber BH. Molecular evolution and functional divergence of the bestrophin protein family. BMC Evol Biol. 2008 Feb 28;8:72.
2007
Weigelt K, Ernst W, Walczak Y, Ebert S, Loenhardt T, Klug M, Rehli M, Weber BH, Langmann T. Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation. J Leukoc Biol. 2007 Dec;82(6):1564-74.
Heimerl S, Bosserhoff AK, Langmann T, Ecker J, Schmitz G. Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells. Melanoma Res. 2007 Oct;17(5):265-73.
Wistuba W, Gnewuch C, Liebisch G, Schmitz G, Langmann T. Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR. World J Gastroenterol. 2007 Aug 21;13(31):4230-5.
Orsó E, Moehle C, Boettcher A, Szakszon K, Werner T, Langmann T, Liebisch G, Buechler C, Ritter M, Kronenberg F, Dieplinger H, Bornstein SR, Stremmel W, Schmitz G. The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases. Horm Metab Res. 2007 Aug;39(8):601-11.
Schifferer R, Liebisch G, Bandulik S, Langmann T, Dada A, Schmitz G. ApoA-I induces a preferential efflux of monounsaturated phosphatidylcholine and medium chain sphingomyelin species from a cellular pool distinct from HDL(3) mediated phospholipid efflux. Biochim Biophys Acta. 2007 Jul;1771(7):853-63.
Langmann T. Microglia activation in retinal degeneration. J Leukoc Biol. 2007 Jun;81(6):1345-51.
Zahn A, Moehle C, Langmann T, Ehehalt R, Autschbach F, Stremmel W, Schmitz G. Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis. World J Gastroenterol. 2007 Mar 21;13(11):1687-95.
Gehrig A, Langmann T, Horling F, Janssen A, Bonin M, Walter M, Poths S, Weber BH. Genome-wide expression profiling of the retinoschisin-deficient retina in early postnatal mouse development. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):891-900.
Ecker J, Langmann T, Moehle C, Schmitz G. Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1c dependent mechanism. Biochem Biophys Res Commun. 2007 Jan 19;352(3):805-11.
Neumeier M, Sigruener A, Eggenhofer E, Weigert J, Weiss TS, Schaeffler A, Schlitt HJ, Aslanidis C, Piso P, Langmann T, Schmitz G, Schölmerich J, Buechler C. High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. Biochem Biophys Res Commun. 2007 Jan 12;352(2):543-8.
Ernst W, Florian C, Langmann T, Weber B, Morsczeck C. Characterization of signal transduction pathways in Muller Glial cells and retinal progenitor cells. J Stem Cells Regen Med. 2007 May 16;2(1):128.